ניווט מהיר
פותח על ידי Startup Booster
תחום מחקר: אימונולוגיה
Synopsis
We are studying multiple aspects of the role of immunopathology in the tumor microenvironment and particularly interested in the role of immune cells in tumorigenesis, the bidirectional cross talk between immune and epithelial cells and how this cross talk affects tissue homeostasis and carcinogenesis. Hepatocellular carcinoma (HCC), one of the deadliest tumors, is a prototype of inflammation induced cancer. Employing mouse models of human HCC and genetic manipulation strategies, coupled to cell isolation and analysis techniques, we are delineating the molecular cues and pathogenetic processes that precede and promote HCC.
מלגות ופרסים
Distinguish Scientist Award in Periodontal Research – IADR 2009Sunstar Award. Best article on perio-systemic connection 2003Finalist in the Jaccard-EFP Research Price Competitio 2000Rizzo Award - IADR periodontal research group 1999Hadassah-Teva award 1996
מחקרים
Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under HypoxiStabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genesThe single translation product of the FUM1 gene (fumarase) is processed in mitochondria before being distributed between the cytosol and mitochondria in Saccharomyces cerevisiaePI3K/AKT/mTOR‐dependent stabilization of oncogenic far‐upstream element binding proteins in hepatocellular carcinoma cellsEctopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinomaAbstract 2157: PI3K/AKT-induced stabilization of FUSE binding proteins (FBPs) in liver cancer cellsRestoring inflammatory balance as a potential preventive strategy for inflammation induced cancerHigh SEPT9_i1 Protein Expression Is Associated with High-Grade Prostate CancersAcquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylationAnimal model studies indicate a candidate biomarker for sorafenib treatment of hepatocellular carcinomaHuman and Mouse VEGFA-Amplified Hepatocellular Carcinomas Are Highly Sensitive to Sorafenib TreatmentSplicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma developmentReceptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation‐associated liver carcinogenesis in miceGenome-Wide Analysis of Androgen Receptor Targets Reveals COUP-TF1 as a Novel Player in Human Prostate CancerRegulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndromeS100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesisThe Chemokine CXCL16 and Its Receptor, CXCR6, as Markers and Promoters of Inflammation-Associated CancersCXCL16 and CXCR6 may promote inflammation-associated cancer growth through autocrine effects on cancer cells and paracrine effects on leukocytesTracking the progression of hepatocellular carcinoma in mouse modelsThe transmembrane chemokine CXCL16 is highly expressed in inflammation-associated cancersNF-κB functions as a tumour promoter in inflammation-associated cancerLyn Is a Target Gene for Prostate CancerSequence-based Design of Kinase Inhibitors Applicable for Therapeutics and Target IdentificationThe Antiangiogenic Agent Linomide Inhibits the Growth Rate of von Hippel-Lindau Paraganglioma Xenografts to MiceIntercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor