ד"ר אור כחלון

תחום מחקר: מדעי המוח

Synopsis

During my PhD I developed novel fluorescence-based methods for determining intracellular labile iron pools. This work, as well as later work after my postdoc as a research associate at the Hebrew University of Jerusalem, allowed me to make significant contributions in the field of bioiron monitoring and modulation, especially in the context of chelator-based therapy for Friedreich’s ataxia.

In my postdoc I studied clathrin coated vesicles (CCVs) which bud from maturing secretory granules in neuroendocrine cells.

The general umbrella of my current research is metabolism. My main focus in the last few years has been glycogen storage disorders and I have made significant contribution to that field by exploring novel methods for curing Adult Polyglucosan Body Disease and Pompe disease. My work on Pompe disease mailnly focuses on autophagy.

In collaboration with Dr. Iris Lavon from our department I have very recently also embarked on yet another metabolism-related research – metabolomics and bioenergetics of glioblastoma.